How might architecture respond to issues of ecology and sustainability whereby buildings behave more like organisms in their built environments? This talk will present ongoing trans-disciplinary research and design spanning across the fields of cell biology, materials science, physics, fiber science, fashion, electrical and systems engineering, and architecture. Sabin’s collaborative research, teaching and design practice focus on the contextual, material and formal intersections between architecture, science and technology. Through the visualization and materialization of dynamic and complex datasets, Sabin has generated a body of speculative and applied design work that aligns crafts-based techniques with digital fabrication alongside questions related to the body and information mediation. The material world that this type of research interrogates reveals examples of nonlinear fabrication and self-assembly at the surface, and at a deeper structural level. In parallel, this work offers up novel possibilities that question and redefine architecture within the greater scope of generative design and fabrication. This talk will elucidate the research methods, prototypes and applications that Sabin and her collaborators have achieved, which aim to radically alter the paradigm of Responsive Architecture through architectural treatments, in the form of adaptive building skins, material assemblies, and architectural interventions that ultimately (re)configure their own performance based upon local criteria.